Identification of Aneuploidy-Selective Antiproliferation Compounds
نویسندگان
چکیده
منابع مشابه
Identification of Aneuploidy-Selective Antiproliferation Compounds
Aneuploidy, an incorrect chromosome number, is a hallmark of cancer. Compounds that cause lethality in aneuploid, but not euploid, cells could therefore provide new cancer therapies. We have identified the energy stress-inducing agent AICAR, the protein folding inhibitor 17-AAG, and the autophagy inhibitor chloroquine as exhibiting this property. AICAR induces p53-mediated apoptosis in primary ...
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Aneuploidy causes a proliferative disadvantage in all normal cells analyzed to date, yet this condition is associated with a disease characterized by unabated proliferative potential, cancer. The mechanisms that allow cancer cells to tolerate the adverse effects of aneuploidy are not known. To probe this question, we identified aneuploid yeast strains with improved proliferative abilities. Thei...
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متن کاملIdentification of phytochemicals, plant compounds Smirnovia iranica.
Background & Aim: Fabaceae plant family cow tail (Smirnovia iranica) is one of the valuable species of native shrubs and sand dunes in the central region of Iran which is consistent with the production of forage and soil conservation and creating a beautiful landscape; it has the active ingredients of medicinal values. The purpose of this study was to investigate the presence of some p...
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ژورنال
عنوان ژورنال: Cell
سال: 2011
ISSN: 0092-8674
DOI: 10.1016/j.cell.2011.01.017